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Cianfrone G, Pentangelo D, Cianfrone F, Mazzei F, Turchetta R, Orlando MP, et al

Inhibition of Tcell inflammatory cytokines, hepatocyte NFkappaB signaling, and HCV infection by standardized silymarin

4.2 Allergic asthma and allergic rhinitis An in vitro model of allergic airway inflammation, BEAS-2B human bronchial epithelial cells, were pre-treated with BBR (1 M) and activated, resulting in significant inhibition of IL-6 and CC motif chemokine ligand (CCL)-11 secretion, possibly through suppression of STAT6 signaling, without affecting cell viability [53]

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For example, GA can trigger mitochondrial apoptotic signals: it upregulates Bax, downregulates Bcl-2, and activates caspase-9 and 3, leading to programmed cell death in various carcinoma cells (148)

Developed by Novo Nordisk, this long-acting amylin analogue works by activating amylin receptors throughout the body, particularly in areas that regulate appetite and digestive function [1]